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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| BEROTRALSTAT
| BEROTRALSTAT | CARDIOVASCULAR | ORAL | Cmax 280.8 NANOMOLAR Tmax 5 HOUR PPB 99 PERCENT HT 93 HOUR SOLUBILITY SOLUBLE IN WATER IF PH LESS THAN 4.5 | KALLIKREIN PDB 7N7X (CRYSTAL STRUCTURE OF BCX7353(ORLADEYO) IN COMPLEX WITH HUMAN PLASMA KALLIKREIN SERINE PROTEASE DOMAIN AT 2.1 ANGSTROM RESOLUTION) LIGAND CODE = 0RI (link to the list of PDB complexes) Download experimental 3D coordinates of 0RI with added hydrogens | Plasma kallikrein UNIPROT P03952 KLKB1 more at DrugCentral | EMA | |||
