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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| LONAFARNIB
| LONAFARNIB | VARIOUS | ORAL | Cmax 2.8 MICROMOLAR Tmax 2 HOUR VD 97.4 LITER PPB 99 PERCENT HT 5 HOUR | FARNESYL PROTEIN TRANSFERASE PDB 1O5M (STRUCTURE OF FPT BOUND TO THE INHIBITOR SCH66336) LIGAND CODE = 336 (link to the list of PDB complexes) Download experimental 3D coordinates of 336 with added hydrogens | Protein farnesyltransferase UNIPROT P49354 FNTA more at DrugCentral | EMA | |||
