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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PRALSETINIB
| PRALSETINIB | ANTINEOPLASTIC | ORAL | Cmax 5.3 MICROMOLAR Tmax 3 HOUR VD 228 LITER PPB 97.1 PERCENT Cl 9.1 LITER / HOUR HT 14.7 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER (LESS THAN 0.001 MILLIGRAM PER MILLILITER) | RET PROTEIN TYROSINE KINASE (IC50 LESS THAN 0.5 NANOMOLAR) PDB 7JU5 (STRUCTURE OF RET PROTEIN TYROSINE KINASE IN COMPLEX WITH PRALSETINIB) LIGAND CODE = Q4J (link to the list of PDB complexes) Download experimental 3D coordinates of Q4J with added hydrogens | Proto-oncogene tyrosine-protein kinase receptor Ret UNIPROT P07949 RET more at DrugCentral | EMA | |||
