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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| SAMIDORPHAN
| SAMIDORPHAN | NERVOUS SYSTEM | ORAL | Cmax 121.7 NANOMOLAR Tmax 1.5 HOUR F 69 PERCENT PPB 28 PERCENT Cl 40 LITER / HOUR HT 9 HOUR | MU-OPIOID RECEPTOR (KI=0.052 NANOMOLAR) KAPPA-OPIOID RECEPTOR (KI=0.23 NANOMOLAR) DELTA-OPIOID RECEPTOR (KI=2.7 NANOMOLAR) | Mu-type opioid receptor UNIPROT P35372 OPRM1 more at DrugCentral | EMA | |||
