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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| UMBRALISIB DISCONTINUED
| UMBRALISIB | ANTINEOPLASTIC | ORAL | Cmax 12.8 MICROMOLAR Tmax 4 HOUR VD 312 LITER PPB 99.7 PERCENT Cl 15.5 LITER / HOUR HT 91 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER (PKA=2.71) | PI3K-DELTA CASEIN KINASE CK1-EPSILON | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform UNIPROT O00329 PIK3CD -- Casein kinase I isoform epsilon UNIPROT P49674 CSNK1E more at DrugCentral | EMA | |||
