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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TIVOZANIB
| TIVOZANIB | ANTINEOPLASTIC | ORAL | Cmax 191 NANOMOLAR Tmax 10 HOUR VD 123 LITER PPB 99 PERCENT Cl 0.75 LITER / HOUR HT 111 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER (0.09 MILLIGRAM PER MILLILITER) | VEGFR-1 VEGFR-2 VEGFR-3 PDGFR-BETA PDB 4ASE (CRYSTAL STRUCTURE OF VEGFR2 (JUXTAMEMBRANE AND KINASE DOMAINS) IN COMPLEX WITH TIVOZANIB (AV-951)) LIGAND CODE = AV9 (link to the list of PDB complexes) Download experimental 3D coordinates of AV9 with added hydrogens | Vascular endothelial growth factor receptor 1 UNIPROT P17948 FLT1 -- Vascular endothelial growth factor receptor 2 UNIPROT P35968 KDR more at DrugCentral | EMA | |||
