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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
EXATECAN

EXATECAN
FAM-TRASTUZUMAB DERUXTECAN-NXKI


ATC L01FD04

ANTINEOPLASTIC
ANTIBODY-DRUG CONJUGATE (ADC)
A TOPOISOMERASE INHIBITOR
TREATMENT OF UNRESECTABLE OR METASTATIC HER2-POSITIVE BREAST CANCER
INTRACELLULAR LINKER LEAVAGE BY LYSOSOMAL ENZYMES
THE MEMBRANE-PERMEABLE DXD CAUSES DNA DAMAGE

INJECTION

Cmax 10.1 NANOMOLAR

PPB 97 PERCENT

Cl 19.2 LITER / HOUR

HT 139.2 HOUR

TOPOISOMERASE

Receptor tyrosine-protein kinase erbB-2 UNIPROT P04626 ERBB2 -- DNA topoisomerase 1 UNIPROT P11387 TOP1

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