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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| EXATECAN
| EXATECAN FAM-TRASTUZUMAB DERUXTECAN-NXKI | ANTINEOPLASTIC | INJECTION | Cmax 10.1 NANOMOLAR PPB 97 PERCENT Cl 19.2 LITER / HOUR HT 139.2 HOUR | TOPOISOMERASE | Receptor tyrosine-protein kinase erbB-2 UNIPROT P04626 ERBB2 -- DNA topoisomerase 1 UNIPROT P11387 TOP1 more at DrugCentral | EMA | |||
