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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| SN38
| SN38 SACITUZUMAB GOVITECAN-HZIY | ANTINEOPLASTIC | INJECTION | Cmax 323.6 NANOMOLAR HT 18 HOUR | TOPOISOMERASE PDB 6VXJ (STRUCTURE OF ABCG2 BOUND TO SN38) LIGAND CODE = RS4 (link to the list of PDB complexes) Download experimental 3D coordinates of RS4 with added hydrogens | DNA topoisomerase 1 UNIPROT P11387 TOP1 -- Tumor-associated calcium signal transducer 2 UNIPROT P09758 TACSTD2 more at DrugCentral | EMA | |||
