SELUMETINIB (has an active metabolite) | SELUMETINIB | ATC L01EE04
ANTINEOPLASTIC TREATMENT OF PEDIATRIC NEUROFIBROMAS (PN) MITOGEN-ACTIVATED PROTEIN KINASE KINASES 1 AND 2 INHIBITOR | ORAL | Cmax 1.74 MICROMOLAR Tmax 1.25 HOUR F 62 PERCENT VD 171 LITER PPB 98.4 PERCENT Cl 8.8 LITER / HOUR HT 6.2 HOUR SOLUBILITY SLIGHTLY SOLUBLE AT PH > 3 | MEK1 MEK2 PDB 4U7Z (MITOGEN-ACTIVATED PROTEIN KINASE KINASE (MEK1) BOUND TO G805) LIGAND CODE = 3EW (link to the list of PDB complexes) Download experimental 3D coordinates of 3EW with added hydrogens | Dual specificity mitogen-activated protein kinase kinase 1 UNIPROT Q02750 MAP2K1 -- Dual specificity mitogen-activated protein kinase kinase 2 UNIPROT P36507 MAP2K2 more at DrugCentral | EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank |