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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
SELUMETINIB (has an active metabolite)

SELUMETINIB


ATC L01EE04

ANTINEOPLASTIC
TREATMENT OF PEDIATRIC NEUROFIBROMAS (PN)
MITOGEN-ACTIVATED PROTEIN KINASE KINASES 1 AND 2 INHIBITOR

ORAL

Cmax 1.74 MICROMOLAR

Tmax 1.25 HOUR

F 62 PERCENT

VD 171 LITER

PPB 98.4 PERCENT

Cl 8.8 LITER / HOUR

HT 6.2 HOUR

SOLUBILITY SLIGHTLY SOLUBLE AT PH > 3

MEK1
MEK2

PDB 4U7Z (MITOGEN-ACTIVATED PROTEIN KINASE KINASE (MEK1) BOUND TO G805)

LIGAND CODE = 3EW (link to the list of PDB complexes)

Download experimental 3D coordinates of 3EW with added hydrogens

Dual specificity mitogen-activated protein kinase kinase 1 UNIPROT Q02750 MAP2K1 -- Dual specificity mitogen-activated protein kinase kinase 2 UNIPROT P36507 MAP2K2

more at DrugCentral

EMA

ANSM (in French)

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SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
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