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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PEMIGATINIB
| PEMIGATINIB | ANTINEOPLASTIC | ORAL | Cmax 236 NANOMOLAR Tmax 1.13 HOUR VD 235 LITER PPB 90.6 PERCENT Cl 10.6 LITER / HOUR HT 15.4 HOUR | FGFR1 FGFR2 FGFR3 PDB 7WCL (CRYSTAL STRUCTURE OF FGFR1 KINASE DOMAIN WITH PEMIGATINIB) LIGAND CODE = 8ZF (link to the list of PDB complexes) Download experimental 3D coordinates of 8ZF with added hydrogens | Fibroblast growth factor receptor 3 UNIPROT P22607 FGFR3 -- Fibroblast growth factor receptor 1 UNIPROT P11362 FGFR1 more at DrugCentral | EMA | |||
