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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| SELPERCATINIB
| SELPERCATINIB | ANTINEOPLASTIC | ORAL | Cmax 5.6 MICROMOLAR Tmax 2 HOUR F 73 PERCENT VD 191 LITER PPB 97 PERCENT Cl 6 LITER / HOUR HT 32 HOUR SOLUBILITY SLIGHTLY SOLUBLE IN WATER | RET VEGFR1 VEGFR3 FGFR1 FGFR2 FGFR3 PDB 7JU6 (STRUCTURE OF RET PROTEIN TYROSINE KINASE IN COMPLEX WITH SELPERCATINIB) LIGAND CODE = Q6G (link to the list of PDB complexes) Download experimental 3D coordinates of Q6G with added hydrogens | Proto-oncogene tyrosine-protein kinase receptor Ret UNIPROT P07949 RET more at DrugCentral | EMA | |||
