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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| AVAPRITINIB
| AVAPRITINIB | ANTINEOPLASTIC | ORAL | Cmax 1.63 MICROMOLAR Tmax 3 HOUR VD 1200 LITER PPB 98.8 PERCENT Cl 19.5 LITER / HOUR HT 44.5 HOUR SOLUBILITY LOWER THAN 0.001 MILLIGRAM PER MILLILITER | PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA (PDGFRA) MAST STEM CELL GROWTH FACTOR RECEPTOR (KIT) PDB 8PQG (C-KIT T670I MUTATED KINASE DOMAIN IN COMPLEX WITH AVAPRITINIB) LIGAND CODE = 9JI (link to the list of PDB complexes) Download experimental 3D coordinates of 9JI with added hydrogens | Mast,stem cell growth factor receptor Kit UNIPROT P10721 KIT -- Platelet-derived growth factor receptor alpha UNIPROT P16234 PDGFRA more at DrugCentral | EMA | |||
