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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| FEDRATINIB
| FEDRATINIB | ANTINEOPLASTIC | ORAL | Cmax 3.44 MICROMOLAR Tmax 3 HOUR VD 1770 LITER PPB 92 PERCENT Cl 13 LITER / HOUR HT 114 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | JANUS ASSOCIATED KINASE 2 INHIBITOR (JAK2) FMS-LIKE TYROSINE KINASE 3 (FLT3) PDB 4PS5 (CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH TG101348) LIGAND CODE = 2TA (link to the list of PDB complexes) Download experimental 3D coordinates of 2TA with added hydrogens | Receptor-type tyrosine-protein kinase FLT3 UNIPROT P36888 FLT3 -- Tyrosine-protein kinase JAK2 UNIPROT O60674 JAK2 more at DrugCentral | EMA | |||
