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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ELEXACAFTOR
| ELEXACAFTOR | RESPIRATORY SYSTEM | ORAL | Cmax 14.6 MICROMOLAR Tmax 6 HOUR F 80 PERCENT VD 53.7 LITER PPB 99 PERCENT Cl 1.18 LITER / HOUR HT 29.8 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER (<1 MG/ML) | CFTR CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PDB 8EIQ (THE COMPLEX OF PHOSPHORYLATED HUMAN DELTA F508 CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) WITH TRIKAFTA [ELEXACAFTOR (VX-445), TEZACAFTOR (VX-661), IVACAFTOR (VX-770)] AND ATP, MG) LIGAND CODE = WJX (link to the list of PDB complexes) Download experimental 3D coordinates of WJX with added hydrogens | Cystic fibrosis transmembrane conductance regulator UNIPROT P13569 CFTR more at DrugCentral | EMA | |||
