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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
FLORTAUCIPIR

FLORTAUCIPIR


ATC V09AX07

VARIOUS
RADIOACTIVE DIAGNOSTIC AGENT
PET IMAGING OF THE BRAIN
ESTIMATES THE DENSITY AND DISTRIBUTION OF AGGREGATED TAU NEUROFIBRILLARY TANGLES (NFTS) (KD = 0.57 NM)
BIND WITH LOW NANOMOLAR AFFINITY TO MONOAMINE OXIDASE-A AND MONOAMINE OXIDASE-B

INTRAVENOUS AGGREGATED TAU NEUROFIBRILLARY TANGLES

PDB 8BYN (CHRONIC TRAUMATIC ENCEPHALOPATHY TAU FILAMENTS WITH PET LIGAND FLORTAUCIPIR)

LIGAND CODE = S9C (link to the list of PDB complexes)

Download experimental 3D coordinates of S9C with added hydrogens

Microtubule-associated protein tau UNIPROT P10636

more at DrugCentral

EMA

ANSM (in French)

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ChEMBL
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