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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PEXIDARTINIB
| PEXIDARTINIB | ANTINEOPLASTIC | ORAL | Cmax 20.6 MICROMOLAR Tmax 2.5 HOUR VD 187 LITER PPB 99 PERCENT Cl 5.1 LITER / HOUR HT 26.6 HOUR SOLUBILITY SLIGHTLY SOLUBLE IN WATER | COLONY STIMULATING ACTOR 1 RECEPTOR (CSF1R) PDB 4R7H (CRYSTAL STRUCTURE OF FMS KINASE DOMAIN WITH A SMALL MOLECULAR INHIBITOR, PLX3397) LIGAND CODE = P31 (link to the list of PDB complexes) Download experimental 3D coordinates of P31 with added hydrogens | Mast,stem cell growth factor receptor Kit UNIPROT P10721 KIT -- Receptor-type tyrosine-protein kinase FLT3 UNIPROT P36888 FLT3 more at DrugCentral | EMA | |||
