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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
LEFAMULIN

LEFAMULIN


ATC J01XX12

ANTIINFECTIVES
PLEUROMUTILIN ANTIBACTERIAL
TREATMENT OF BACTERIAL PNEUMONIA (CABP)
INTERACTS WITH A- AND P-SITES OF THE PEPTIDYL TRANSFERASE CENTER (PTC) IN DOMAIN V OF THE 23S RRNA OF THE 50S SUBUNIT

ORAL INTRAVENOUS

Cmax 7 MICROMOLAR

Tmax 1.4 HOUR

F 25 PERCENT

VD 86.1 LITER

PPB 94.8 PERCENT

Cl 11.9 LITER / HOUR

HT 8 HOUR

RIBOSOMAL SUBUNIT 50S

PDB 5HL7 (THE CRYSTAL STRUCTURE OF THE LARGE RIBOSOMAL SUBUNIT OF STAPHYLOCOCCUS AUREUS IN COMPLEX WITH LEFAMULIN)

LIGAND CODE = 62B (link to the list of PDB complexes)

Download experimental 3D coordinates of 62B with added hydrogens

Unknown

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EMA

ANSM (in French)

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