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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PITOLISANT
| PITOLISANT | NERVOUS SYSTEM | ORAL | Cmax 247 NANOMOLAR Tmax 3.5 HOUR F 90 PERCENT VD 700 LITER PPB 93.5 PERCENT Cl 43.9 LITER / HOUR HT 20 HOUR SOLUBILITY SOLUBLE IN WATER | HISTAMINE-3 (H3) RECEPTOR | Histamine H3 receptor UNIPROT Q9Y5N1 HRH3 more at DrugCentral | EMA | |||
