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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| LUMATEPERONE
| LUMATEPERONE | NERVOUS SYSTEM | ORAL | Tmax 1.5 HOUR F 4.4 PERCENT VD 266.5 LITER (65 KILOGRAM) PPB 97.4 PERCENT Cl 27.9 LITER / HOUR HT 18 HOUR | 5-HT2A RECEPTORS DOPAMINE D2 RECEPTORS PDB 7WC8 (CRYSTAL STRUCTURE OF SEROTONIN 2A RECEPTOR IN COMPLEX WITH LUMATEPERONE) LIGAND CODE = 92S (link to the list of PDB complexes) Download experimental 3D coordinates of 92S with added hydrogens | D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A more at DrugCentral | EMA | |||
