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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ISTRADEFYLLINE
| ISTRADEFYLLINE | NERVOUS SYSTEM | ORAL | Tmax 4 HOUR VD 557 LITER PPB 98 PERCENT Cl 4.6 LITER / HOUR HT 83 HOUR SOLUBILITY 0.6 MICROGRAM PER MILLILITER IN WATER | ADENOSINE RECEPTOR A2A PDB 8GNG (CRYSTAL STRUCTURE OF HUMAN ADENOSINE A2A RECEPTOR IN COMPLEX WITH ISTRADEFYLLINE) LIGAND CODE = JQ9 (link to the list of PDB complexes) Download experimental 3D coordinates of JQ9 with added hydrogens | Adenosine receptor A2a UNIPROT P29274 ADORA2A more at DrugCentral | EMA | |||
