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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ERDAFITINIB
| ERDAFITINIB | ANTINEOPLASTIC | ORAL | Cmax 3.1 MICROMOLAR Tmax 2.5 HOUR VD 29 LITER PPB 99.8 PERCENT Cl 0.362 LITER / HOUR HT 59 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | FGFR1 FGFR2 FGFR3 FGFR4 PDB 5EW8 (FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH JNJ-4275693) LIGAND CODE = 5SF (link to the list of PDB complexes) Download experimental 3D coordinates of 5SF with added hydrogens | Vascular endothelial growth factor receptor 2 UNIPROT P35968 KDR -- Fibroblast growth factor receptor 3 UNIPROT P22607 FGFR3 more at DrugCentral | EMA | |||
