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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TALAZOPARIB
| TALAZOPARIB | ANTINEOPLASTIC | ORAL | Cmax 43 NANOMOLAR Tmax 1.5 HOUR VD 420 LITER PPB 74 PERCENT Cl 6.45 LITER / HOUR HT 90 HOUR | POLYADENOSINE 5-DIPHOSPHORIBOSE POLYMERASE (PARP) PDB 4UND (HUMAN ARTD1 (PARP1)) LIGAND CODE = 2YQ (link to the list of PDB complexes) Download experimental 3D coordinates of 2YQ with added hydrogens | Poly ADP-ribose polymerase 1 UNIPROT P09874 PARP1 -- Poly ADP-ribose polymerase 2 UNIPROT Q9UGN5 PARP2 more at DrugCentral | EMA | |||
