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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| BREXANOLONE
| BREXANOLONE | NERVOUS SYSTEM | INTRAVENOUS | Cmax 163 NANOMOLAR VD 195 LITER (65 KILOGRAM) PPB 99 PERCENT Cl 65 LITER / HOUR (65 KILOGRAM) HT 9 HOUR | GAMMA-AMINOBUTYRIC ACID (GABA) A RECEPTOR PDB 8G4N (NATIVE GABA-A RECEPTOR FROM THE MOUSE BRAIN, ALPHA1-BETA2-GAMMA2 SUBTYPE, IN COMPLEX WITH GABA, ZOLPIDEM, AND ENDOGENOUS NEUROSTEROIDS) LIGAND CODE = Y4B (link to the list of PDB complexes) Download experimental 3D coordinates of Y4B with added hydrogens | Gamma-aminobutyric acid receptor subunit alpha-1 UNIPROT P14867 GABRA1 more at DrugCentral | EMA | |||
