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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| GILTERITINIB
| GILTERITINIB | ANTINEOPLASTIC | ORAL | Cmax 0.67 MICROMOLAR Tmax 5 HOUR VD 1092 LITER PPB 94 PERCENT Cl 14.85 LITER / HOUR HT 113 HOUR SOLUBILITY SPARINGLY SOLUBLE IN WATER | FMS-LIKE TYROSINE KINASE 3 (FLT3) PDB 6JQR (CRYSTAL STRUCTURE OF FLT3 IN COMPLEX WITH GILTERITINIB) LIGAND CODE = C6F (link to the list of PDB complexes) Download experimental 3D coordinates of C6F with added hydrogens | Receptor-type tyrosine-protein kinase FLT3 UNIPROT P36888 FLT3 more at DrugCentral | EMA | |||
