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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DUVELISIB
| DUVELISIB | ANTINEOPLASTIC | ORAL | Cmax 3.6 MICROMOLAR Tmax 1.5 HOUR F 42 PERCENT VD 28.5 LITER PPB 98 PERCENT Cl 4.2 LITER / HOUR HT 4.7 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | PI3K | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform UNIPROT O00329 PIK3CD -- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform UNIPROT P48736 PIK3CG more at DrugCentral | EMA | |||
