| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| RIFAMYCIN
| RIFAMYCIN |
ANTIINFECTIVES | ORAL | Cmax 12.5 NANOMOLAR Tmax 6 HOUR F 0.1 PERCENT PPB 80 PERCENT SOLUBILITY SOLUBLE IN WATER | BETA-SUBUNIT DNA-DEPENDENT RNA POLYMERASE PDB 6BEB (CRYSTAL STRUCTURE OF VACV D13) LIGAND CODE = RFV (link to the list of PDB complexes) Download experimental 3D coordinates of RFV with added hydrogens | DNA-directed RNA polymerase subunit beta UNIPROT P0A8V2 rpoB more at DrugCentral | EMA | |||
