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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| LORLATINIB
| LORLATINIB | ANTINEOPLASTIC | ORAL | Cmax 1.42 MICROMOLAR Tmax 1.2 HOUR F 81 PERCENT VD 305 LITER PPB 66 PERCENT Cl 11 LITER / HOUR HT 24 HOUR SOLUBILITY 0.17 MILLIGRAM PER MILLILITER | ALK ROS1 PDB 5A9U (HUMAN ANAPLASTIC LYMPHOMA KINASE) LIGAND CODE = 5P8 (link to the list of PDB complexes) Download experimental 3D coordinates of 5P8 with added hydrogens | ALK tyrosine kinase receptor UNIPROT Q9UM73 ALK -- Proto-oncogene tyrosine-protein kinase ROS UNIPROT P08922 ROS1 more at DrugCentral | EMA | |||
