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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
BALOXAVIR (is an active metabolite)

BALOXAVIR


ATC J05AX25

ANTIINFECTIVES
PRODRUG
POLYMERASE ACIDIC (PA) ENDONUCLEASE INHIBITOR
TREATMENT OF ACUTE UNCOMPLICATED INFLUENZA

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Cmax 199 NANOMOLAR

Tmax 4 HOUR

VD 1180 LITER

PPB 93.4 PERCENT

Cl 10.3 LITER / HOUR

HT 79.1 HOUR

POLYMERASE ACIDIC PROTEIN

PDB 6FS6 (INFLUENZA A, CALIFORNIA 04 2009 (PH1N1) ENDONUCLEASE)

LIGAND CODE = E4Z (link to the list of PDB complexes)

Download experimental 3D coordinates of E4Z with added hydrogens

Polymerase acidic protein UNIPROT P03433

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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