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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| BINIMETINIB
| BINIMETINIB | ANTINEOPLASTIC | ORAL | Tmax 1.6 HOUR F 50 PERCENT VD 92 LITER PPB 97 PERCENT Cl 20.2 LITER / HOUR HT 3.5 HOUR SOLUBILITY INSOLUBLE IN WATER AT PH 4.5 AND HIGHER | MEK1 AND MEK2 PDB 7M0U (CRYSTAL STRUCTURE OF THE BRAF:MEK1 KINASES IN COMPLEX WITH AMPPNP AND BINIMETINIB) LIGAND CODE = QO7 (link to the list of PDB complexes) Download experimental 3D coordinates of QO7 with added hydrogens | Dual specificity mitogen-activated protein kinase kinase 1 UNIPROT Q02750 MAP2K1 -- Dual specificity mitogen-activated protein kinase kinase 2 UNIPROT P36507 MAP2K2 more at DrugCentral | EMA | |||
