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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| SIPONIMOD
| SIPONIMOD | IMMUNOSUPPRESSANTS | ORAL | Cmax 58.8 NANOMOLAR Tmax 4 HOUR F 84 PERCENT VD 124 LITER PPB 99.9 PERCENT Cl 3.11 LITER / HOUR HT 30 HOUR | SPHINGOSINE 1-PHOSPHATE RECEPTOR (S1P) PDB 7EVY (CRYO-EM STRUCTURE OF SIPONIMOD -BOUND SPHINGOSINE-1-PHOSPHATE RECEPTOR 1 IN COMPLEX WITH GI PROTEIN) LIGAND CODE = J8C (link to the list of PDB complexes) Download experimental 3D coordinates of J8C with added hydrogens | Sphingosine 1-phosphate receptor 1 UNIPROT P21453 S1PR1 -- Sphingosine 1-phosphate receptor 5 UNIPROT Q9H228 S1PR5 more at DrugCentral | EMA | |||
