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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| MIGALASTAT
| MIGALASTAT | METABOLISM | ORAL | Tmax 3 HOUR F 75 PERCENT VD 89 LITER PPB 0 PERCENT Cl 12.5 LITER / HOUR HT 4 HOUR SOLUBILITY FREELY SOLUBLE IN AQUEOUS MEDIA WITHIN THE PH RANGE OF 1.2 TO 7.5 | ALPHA-GALACTOSIDASE A PDB 4D1J (THE STRUCTURE OF THE GH35 BETA-GALACTOSIDASE BGL35A FROM CELLVIBRIO JAPONICAS IN COMPLEX WITH 1-DEOXYGALACTONOJIRIMYCIN) LIGAND CODE = DGJ (link to the list of PDB complexes) Download experimental 3D coordinates of DGJ with added hydrogens | Alpha-galactosidase A UNIPROT P06280 GLA more at DrugCentral | EMA | |||
