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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| BICTEGRAVIR
| BICTEGRAVIR | ANTIINFECTIVES | ORAL | Cmax 13.6 MICROMOLAR Tmax 3 HOUR PPB 99 PERCENT HT 17.3 HOUR SOLUBILITY 0.1 MILLIGRAM PER MILLILITER IN WATER | INTEGRASE STRAND TRANSFER PDB 6PUW (STRUCTURE OF HIV CLEAVED SYNAPTIC COMPLEX (CSC) INTASOME BOUND WITH MAGNESIUM AND BICTEGRAVIR (BIC)) LIGAND CODE = KLQ (link to the list of PDB complexes) Download experimental 3D coordinates of KLQ with added hydrogens | Integrase UNIPROT Q7ZJM1 pol more at DrugCentral | EMA | |||
