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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| COCAINE
| COCAINE | NATURAL MOLECULE (link)
NERVOUS SYSTEM | NASAL | Cmax 142.4 NANOMOLAR Tmax 0.42 HOUR VD 3877 LITER PPB 88 PERCENT Cl 3096 LITER / HOUR HT 1.3 HOUR | SODIUM CHANNELS PDB 1Q72 (ANTI-COCAINE ANTIBODY M82G2 COMPLEXED WITH COCAINE) LIGAND CODE = COC (link to the list of PDB complexes) Download experimental 3D coordinates of COC with added hydrogens | Sodium-dependent dopamine transporter UNIPROT Q01959 SLC6A3 more at DrugCentral | EMA | |||
