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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| COPANLISIB DISCONTINUED
| COPANLISIB | ANTINEOPLASTIC | INTRAVENOUS | Cmax 964 NANOMOLAR VD 871 LITER PPB 84.2 PERCENT Cl 17.9 LITER / HOUR HT 39.1 HOUR | PHOSPHATIDYLINOSITOL-3-KINASE (PI3K) PDB 5G2N (X-RAY STRUCTURE OF PI3KINASE GAMMA IN COMPLEX WITH COPANLISIB) LIGAND CODE = 6E2 (link to the list of PDB complexes) Download experimental 3D coordinates of 6E2 with added hydrogens | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform UNIPROT O00329 PIK3CD -- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform UNIPROT P42336 PIK3CA more at DrugCentral | EMA | |||
