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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ABEMACICLIB
| ABEMACICLIB | ANTINEOPLASTIC | ORAL | Tmax 8 HOUR F 45 PERCENT (200 MILLIGRAM) VD 690.3 LITER PPB 96.3 PERCENT HT 18.3 HOUR | CYCLIN-DEPENDENT KINASES 4 AND 6 (CDK4 AND CDK6) PDB 5L2S (THE X-RAY CO-CRYSTAL STRUCTURE OF HUMAN CDK6 AND ABEMACICLIB) LIGAND CODE = 6ZV (link to the list of PDB complexes) Download experimental 3D coordinates of 6ZV with added hydrogens | Cyclin-dependent kinase 6 UNIPROT Q00534 CDK6 -- Cyclin-dependent kinase 4 UNIPROT P11802 CDK4 more at DrugCentral | EMA | |||
