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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| BARICITINIB
| BARICITINIB | IMMUNOMODULATING | ORAL | Tmax 1 HOUR F 80 PERCENT VD 76 LITER PPB 50 PERCENT Cl 8.9 LITER / HOUR HT 12 HOUR | JANUS KINASES (JAK) PDB 4W9X (CRYSTAL STRUCTURE OF BMP-2-INDUCIBLE KINASE IN COMPLEX WITH BARICITINIB) LIGAND CODE = 3JW (link to the list of PDB complexes) Download experimental 3D coordinates of 3JW with added hydrogens | Tyrosine-protein kinase JAK1 UNIPROT P23458 JAK1 -- Tyrosine-protein kinase JAK2 UNIPROT O60674 JAK2 more at DrugCentral | EMA | |||
