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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| RIBOCICLIB
| RIBOCICLIB | ANTINEOPLASTIC | ORAL | Tmax 2.5 HOUR VD 1090 LITER PPB 70 PERCENT Cl 25.5 LITER / HOUR HT 32 HOUR | CDK-4 CDK-6 PDB 5L2T (THE X-RAY CO-CRYSTAL STRUCTURE OF HUMAN CDK6 AND RIBOCICLIB.) LIGAND CODE = 6ZZ (link to the list of PDB complexes) Download experimental 3D coordinates of 6ZZ with added hydrogens | Cyclin-dependent kinase 6 UNIPROT Q00534 CDK6 -- Cyclin-dependent kinase 4 UNIPROT P11802 CDK4 more at DrugCentral | EMA | |||
