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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| BRIGATINIB
| BRIGATINIB | ANTINEOPLASTIC | ORAL | Cmax 2.4 MICROMOLAR Tmax 2.5 HOUR VD 153 LITER PPB 66 PERCENT Cl 12.7 LITER / HOUR HT 25 HOUR | ALK KINASE ROS1 IGF-1R FLT-3 EGFR PDB 5J7H (CRYSTAL STRUCTURE OF ANAPLASTIC LYMPHOMA KINASE (ALK) BOUND BY BRIGATINIB) LIGAND CODE = 6GY (link to the list of PDB complexes) Download experimental 3D coordinates of 6GY with added hydrogens | ALK tyrosine kinase receptor UNIPROT Q9UM73 ALK more at DrugCentral | EMA | |||
