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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
L-GLUTAMINE

L-GLUTAMINENATURAL MOLECULE (link)


ATC A16AA03

BLOOD
AMINOACID INDICATED TO REDUCE THE ACUTE COMPLICATIONS OF SICKLE CELL DISEASE (SCD)
L-GLUTAMINE MAY IMPROVE THE NAD REDOX POTENTIAL IN SICKLE RBCS THROUGH INCREASING THE AVAILABILITY OF REDUCED GLUTATHIONE

ORAL

Cmax 1028 MICROMOLAR

Tmax 0.5 HOUR

VD 13 LITER (65 KILOGRAM)

HT 1 HOUR

PDB 2F2A (STRUCTURE OF TRNA-DEPENDENT AMIDOTRANSFERASE GATCAB COMPLEXED WITH GLN)

LIGAND CODE = GLN (link to the list of PDB complexes)

Download experimental 3D coordinates of GLN with added hydrogens

Amino acid transporter UNIPROT Q9Z1J7

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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