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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| NERATINIB
| NERATINIB | ANTINEOPLASTIC | ORAL | Tmax 5 HOUR VD 6433 LITER PPB 99 PERCENT Cl 281 LITER / HOUR HT 14.6 HOUR SOLUBILITY SPARINGLY SOLUBLE AT PH 1.2 (32.90 MG/ML) AND INSOLUBLE AT APPROXIMATE PH 5.0 AND ABOVE (0.08 MG/ML OR LESS) | EGFR HER2 HER4 | Receptor tyrosine-protein kinase erbB-4 UNIPROT Q15303 ERBB4 -- Epidermal growth factor receptor UNIPROT P00533 EGFR more at DrugCentral | EMA | |||
