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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
LIFITEGRAST

LIFITEGRAST


ATC S01XA25

SENSORY
TREATMENT OF THE SIGNS AND SYMPTOMS OF DRY EYE DISEASE (DED)
LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1 (LFA-1) ANTAGONIST
LFA-1 IS A CELL SURFACE PROTEIN FOUND ON LEUKOCYTES AND BLOCKS THE INTERACTION OF LFA-1 WITH ITS COGNATE LIGAND INTERCELLULAR ADHESION MOLECULE-1 (ICAM-1)

OPHTHALMIC

Cmax 900 PICOMOLAR

SOLUBILITY SOLUBLE IN WATER

LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1 (LFA-1)

Integrin alpha-L,beta-2 UNIPROT P20701 ITGAL

more at DrugCentral

EMA

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