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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| VENETOCLAX
| VENETOCLAX | ANTINEOPLASTIC | ORAL | Cmax 2.42 MICROMOLAR Tmax 6.5 HOUR VD 288 LITER PPB 99.9 PERCENT HT 26 HOUR SOLUBILITY LOW SOLUBILITY IN WATER | BCL-2 PDB 6O0K (CRYSTAL STRUCTURE OF BCL-2 WITH VENETOCLAX) LIGAND CODE = LBM (link to the list of PDB complexes) Download experimental 3D coordinates of LBM with added hydrogens | Apoptosis regulator Bcl-2 UNIPROT P10415 BCL2 more at DrugCentral | EMA | |||
