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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| OBETICHOLIC ACID
| OBETICHOLIC ACID | METABOLISM | ORAL | Tmax 1.5 HOUR VD 618 LITER PPB 99 PERCENT SOLUBILITY SOLUBLE IN WATER PH DEPENDENT | FARNESOID X RECEPTOR (FXR) PDB 1OT7 (STRUCTURAL BASIS FOR 3-DEOXY-CDCA BINDING AND ACTIVATION OF FXR) LIGAND CODE = CHC (link to the list of PDB complexes) Download experimental 3D coordinates of CHC with added hydrogens | Bile acid receptor UNIPROT Q96RI1 NR1H4 more at DrugCentral | EMA | |||
