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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| LESINURAD DISCONTINUED
| LESINURAD | MUSCULO-SKELETAL | ORAL | Cmax 14.8 MICROMOLAR Tmax 2.5 HOUR F 100 PERCENT VD 20 LITER PPB 98 PERCENT Cl 6 LITER / HOUR HT 5 HOUR SOLUBILITY SOLUBLE IN WATER | URIC ACID TRANSPORTER 1 (URAT1) ORGANIC ANION TRANSPORTER 4 (OAT4) PDB 9B1H (HUMAN URATE TRANSPORTER 1 URAT1 IN COMPLEX WITH LESINURAD) LIGAND CODE = A1AIL (link to the list of PDB complexes) Download experimental 3D coordinates of A1AIL with added hydrogens | Solute carrier family 22 member 12 UNIPROT Q96S37 SLC22A12 more at DrugCentral | EMA | |||
