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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PIMAVANSERIN (has an active metabolite)
| PIMAVANSERIN | NERVOUS SYSTEM | ORAL | Tmax 6 HOUR VD 2173 LITER PPB 95 PERCENT HT 57 HOUR SOLUBILITY SOLUBLE IN WATER | 5-HT2A RECEPTOR 5-HT2C RECEPTOR PDB 8ZMG (CRYSTAL STRUCTURE OF AN INVERSE AGONIST ANTIPSYCHOTIC DRUG PIMAVANSERIN-BOUND 5-HT2A) LIGAND CODE = A1L11 (link to the list of PDB complexes) Download experimental 3D coordinates of A1L11 with added hydrogens | 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A more at DrugCentral | EMA | |||
