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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
ROLAPITANT

ROLAPITANT


ATC A04AD14

NERVOUS SYSTEM
TREATMENT OF NAUSEA AND VOMITING INDUCED BY CANCER CHEMOTHERAPY
SUBSTANCE P/NEUROKININ 1 (NK1) RECEPTOR ANTAGONIST

ORAL INTRAVENOUS

Cmax 1.9 MICROMOLAR

Tmax 4 HOUR

VD 460 LITER

PPB 99.8 PERCENT

Cl 0.96 LITER / HOUR

HT 176 HOUR

P/NEUROKININ-1 (NK1) RECEPTOR

Substance-P receptor UNIPROT P25103 TACR1

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