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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ISAVUCONAZOLE (is an active metabolite)
| ISAVUCONAZOLE | ANTIINFECTIVES | - | Cmax 27.9 MICROMOLAR Tmax 2.5 HOUR F 98 PERCENT VD 450 LITER PPB 99 PERCENT Cl 2.4 LITER / HOUR (EQN) HT 130 HOUR | LANOSTEROL 14 ALPHA-DEMETHYLASE (CYTOCHROME P450 P-45014DM PMID26598096) PDB 6UX0 (ISAVUCONAZOLE BOUND COMPLEX OF ACANTHAMOEBA CASTELLANII CYP51) LIGAND CODE = QKM (link to the list of PDB complexes) Download experimental 3D coordinates of QKM with added hydrogens | Unknown more at DrugCentral | EMA | |||
