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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| IVABRADINE
| IVABRADINE |
CARDIOVASCULAR | ORAL | Tmax 1 HOUR F 40 PERCENT VD 100 LITER PPB 70 PERCENT Cl 24 LITER / HOUR HT 6 HOUR | HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED (HCN) CHANNEL | Potassium,sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 UNIPROT O60741 HCN1 -- Potassium,sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 UNIPROT Q9UL51 HCN2 more at DrugCentral | EMA | |||
