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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| LUMACAFTOR
| LUMACAFTOR | RESPIRATORY SYSTEM | ORAL | Cmax 55.3 MICROMOLAR Tmax 4 HOUR VD 86 LITER PPB 99 PERCENT Cl 2.38 LITER / HOUR HT 25.2 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | CFTR CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PDB 7SVD (THE COMPLEX OF PHOSPHORYLATED HUMAN CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) WITH ATP, MG AND LUMACAFTOR (VX-809)) LIGAND CODE = VX8 (link to the list of PDB complexes) Download experimental 3D coordinates of VX8 with added hydrogens | Cystic fibrosis transmembrane conductance regulator UNIPROT P13569 CFTR more at DrugCentral | EMA | |||
