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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
M CARBAMAZEPINE (is an active metabolite)

 CARBAMAZEPINE


ATC N03AF01

NERVOUS SYSTEM
ANTICONVULSANT
ANALGESIC
ANTIMANIC AGENTS
SPECIFIC ANALGESIC FOR TRIGEMINAL NEURALGIA
CARBAMAZEPINE INDUCES ITS OWN METABOLISM
MECHANISM OF ACTION UNKNOWN (NUMEROUS PHARMACOLOGICAL EFFECTS HAVE BEEN DESCRIBED MODULATION OF ION CHANNELS (SODIUM AND CALCIUM), RECEPTOR-MEDIATED NEUROTRANSMISSION (GABAERGIC, GLUTAMATERGIC, AND MONOAMINERGIC), AND INTRACELLULAR SIGNALING PATHWAYS)

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Cmax 8.7 MICROMOLAR

Tmax 14 HOUR

PPB 50 PERCENT

HT 34 HOUR

 VOLTAGE-GATED SODIUM CHANNELS

 Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A -- Sodium channel protein type 4 subunit alpha UNIPROT P35499 SCN4A

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